Abstract
Analgesics are one of the groups of therapeutic drugs most frequently associated with adverse events (AEs). Opioids and non-opioids are the two main groups of analgesics. Paracetamol and ibuprofen are widely prescribed to paediatric patients as antipyretic and analgesic agents. Opioid analgesics are a wise choice for treatment of moderate or severe pain in paediatric patients. Analgesics are one of the drug classes most frequently associated with adverse events (AEs). Paracetamol and ibuprofen as non-opioid agents have less adverse effects profile than opioids. Respiratory depression is the most serious AE associated with opioids.

Key words: Analgesics, Children, Paediatric, Adverse drug reactions